As 2018 marks the 25th anniversary of the International Reference Centre for the rights of children deprived of their family (ISS/IRC), the ISS/IRC celebrated on October 4th this event with its partners and collaborators, who have been providing their continuous and invaluable support since its foundation in 1997. During a one day conference, selected themes in alternative care, adoption and surrogacy were debated to reflect on the achievements of the last decades and exchange on future challenges in these fields. This symposium was followed by an evening of festivities. The ISS/IRC would like to reiterate its gratitude to the numerous participants (from Central adoption authorities, international experts, members of the ISS network, etc.) and to the supporters who were unfortunately not able to attend the event.